Myasthenia Gravis (MG)

Myasthenia Gravis (MG)

Myasthenia Gravis and you

Welcome to the MG area of the JanssenWithMe platform, dedicated to helping people understand more about myasthenia gravis (MG).

Receiving a diagnosis of MG can be overwhelming, since the disease can affect not only your physical abilities but also your overall quality of life. MG is characterised by weakness in the voluntary muscles, which are muscles consciously controlled by the brain. Because these muscles are attached to the skeleton throughout the body and control body movement, people living with MG can find daily physical activities challenging. The symptoms of MG are often unpredictable and may fluctuate, which requires adjustments in everyday activities to accommodate the symptoms when living with the disease.

By enhancing understanding of MG, its symptoms and the treatment options available, people living with MG, as well as their carers and loved ones, can play a more active role in care, should they wish. Knowledge and understanding of MG can empower people living with the condition and their caregivers to make informed decisions during medical consultations and to tailor care plans according to specific needs.

Here, we aim to provide trusted and reliable information to help further understanding about the journey of living with MG. More updates are planned for this website, so stay tuned over the coming months. For specific medical advice, always consult your healthcare team as your first point of contact.

Patient Perspective

“My symptoms with myasthenia [MG] can vary from hour to hour, day to day, week to week, month to month. There's no knowing one day how I'm going to feel later on in the same day. I might have reasonably well-controlled symptoms in the morning, but by the evening I may not be able to get up and down the stairs. So, every day is a little bit of its own adventure with symptoms of myasthenia, and there's really no predictability.” – MG Patient, UK

Key topics

About MG
Gain an overview of MG, what it is, what causes it and the path to an MG diagnosis.

References

Myasthenia Gravis Foundation of America (MGFA). A Manual for the Healthcare Provider. Available at: https://myasthenia.org/Portals/0/Provider%20Manual_ibook%20version.pdf Last accessed: June 2024.
National Institute of Neurological Disorders and Stroke (NINDS). Myasthenia Gravis. Available at: https://www.ninds.nih.gov/health-information/disorders/myasthenia-gravis Last accessed: June 2024.
Dewilde S, et al. People Diagnosed with Myasthenia Gravis have Lower health-related quality of life and Need More Medical and Caregiver Help in Comparison to the General Population: Analysis of Two Observational Studies. Adv Ther. Vol 40, 4377–4394 (2023). Available at: https://doi.org/10.1007/s12325-023-02604-z Last accessed: June 2024.
Mahic, et al. Healthcare resource use in myasthenia gravis: a US health claims analysis. Ther Adv Neurol Disorders (2023). Available at: https://doi.org/10.1177/17562864221150327 Last accessed: June 2024.
Daum P et al. Perioperative management of myasthenia gravis. BJA Education (2021) 21(11): 414e419
John Hopkins Medicine. Myasthenia Gravis. Available at: https://www.hopkinsmedicine.org/health/conditions-and-diseases/myasthenia-gravis Last accessed: June 2024.
Mishra A, et al. Myasthenia Gravis: A Systematic Review. Cureus (2023) 15(12): e50017. DOI 10.7759/cureus.50017.
Luo H, Xie S, Ma C, Zhang W, Tschöpe C, Fa X, Cheng J, Cao J. Correlation Between Thymus Radiology and Myasthenia Gravis in Clinical Practice. Front Neurol. 2019 Jan 15;9:1173. doi: 10.3389/fneur.2018.01173. PMID: 30697185; PMCID: PMC6340958.
Chen J, Tian D-C, Zhang C, et al. Incidence, mortality, and economic burden of myasthenia gravis in China: A nationwide population-based study. The Lancet Regional Health - Western Pacific. 2020;5(100063). https://doi.org/10.1016/j.lanwpc.2020.100063.
Lazaridis K, et al. Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics. Front Immunol. 2020 Feb 14;11:212. doi: 10.3389/fimmu.2020; 00212. Last accessed: June 2024.
Myasthenia Gravis Foundation of America (MGFA). Seronegative MG Resource Center. Available at: https://myasthenia.org/Newly-Diagnosed/Seronegative-MG-Resource-Center Last accessed: June 2024.
Jackson et al. Understanding the symptom burden and impact of myasthenia gravis from the patient’s perspective: A qualitative study. Neurology and Therapy. 2022;12:1; 107–128. Available at: https://doi.org/10.1007/s40120-022-00408-x.
Myasthenia Gravis Foundation of America (MGFA). Myasthenia Gravis Clinical Overview. Available at: https://myasthenia.org/Professionals/Clinical-Overview-of-MG#DIAGNOSTIC. Last accessed: June 2024
NHS. Myasthenia Gravis. Available at: https://www.nhs.uk/conditions/myasthenia-gravis/ Last accessed: June 2024.
NHS. Diagnosis Myasthenia Gravis. Available at: https://www.nhs.uk/conditions/myasthenia-gravis/diagnosis/ Last accessed: June 2024.